24.03.19 (ȭ) 11:27

Dailypharm

X
̿ 峻,
ϸ 2017-01-14 06:14:52
̿ 峻,
ϸ 2017-01-14 06:14:52
-峻-ұ-պұ



[4]ι̿ƽ

峻 ֿ Ĺ ȭ ̴. ü ұ ̵ Ƿγ , ü , 񸸵 缺 ı, к ȯ ٺ ۿ ִ. ̴ 峻 Ŀ , Ž Ǵ ޼ ɰ ̰ ְ ϴ 峻 ұ ռ ó ſ » ̻ ʷ ְ ȴ. -峻 -» ̻ Ǵ ȯ ߻ 谡 ü ¸ Ǵϴµ ־ ſ ߿ ٽ ȴ.

峻 ܿ , ȯ, , Ʈ ؼ ̸ŭ ߿ . ׷ٸ ̳  峻 ȭ ִ ϱ?

峻 (gut microbiota) и ¿ , ̿ 鼭 ȴ. ˷ ֵ ڿиÿ ü ѿ Bacteroides, Bifidobacterium, Parabacteroides, Escherichia, Shigella, ÿ ü Ǻο ȯ濡 Enterobacter, Haemophilus, Streptococcus, Staphylococcus, Veillonella ʷ 峻 1⵿ ޼ ȭ ġ Ǿ ֿ Clostridium coccoides group, Clostridium botulinum group, BacteroidesVeillonela gerera, Akkermansia muciniphila ǥǴ Verrucomicrobia phylum ֿ ϰ ȴ. Ư ϰ Ǹ Bifidobacterium, Lactobacillus, Enterococcus, Staphylococcus 峻 ȭ ⿩ ִ. ̷ 鼭 ̹ ƽ κ 峻 پ缺 ȴ.

Ǹ phylum() پ缺 7 ҵǸ 1 archaeal phylum( ) ȴ. ֿ phylum , Lachnospiraceae, Ruminococcaceae families Firmicutes Bacteroidaceae, Prevotellaceae , Rikenellaceae families Bacteroidetes, ׸ Bifidobacteriaceae , Coriobacteriaceae families Actinobacteria Ѱ ź (methanogenic archaeon) Methanobrevibacter smithii ǰ 峻 ָ ̷ Ǹ Proteobacteria, Fusobacteria, Verrucomicrobia Cyanobacteria ϰ ִ.

MetaHIT Consortium (Metagenomics of the Human Intestinal Tract consortium) ǰ Ϲ 峻 3 (enterotype:ֿ ׸Ƹ ü з) зϰ ִ. 1 (enterotype 1) Bacteroides ָ ̷ ؼ Ÿ, 2 Prevotella ½ ܹ ıɷ, 3 Ruminococcus ½ ı ɷ .

ֱ з metagenomics analysis high gene count (HGC) carriers low gene count (LGC) carriers 峻 · з ̱ ѵ, 峻 κ ſ پϱ⿡, ̷ ܼȭ ִٰ ִ. ׷ ̳ ȯ濡 ٽ 簡 Ǵ ̴. metagenomics(Ǵ metabolomics) м ü ſ ߿ ǹ̸ ϰ Ǹ ϴ .

峻 µ, pH ȯ , о, , , , ̵ غ (Ǵ ) ɿ ؼ ¿ǹǷ, ȯ濡 ȭ ִ. ׷ ̵ ȭ߿ źȭ, , ܹ ֿ Ҹ ϴ ȭȿҰ ʴ 忡 ַ ϰ ִ. ȭ ȭ κ ϴ oligo- Ǵ polysaccharides յ鿡 ȿǾ ܼ(SCFA, short chain fatty acid)  (phenolic compound) Ǹ ̵ Ȱ ̾. ̷ ؼ δ Bacteroides, Bifidobacterium, Clostridium, Eubacterium, Lactobacillus, Ruminococcus genera ִ. ȭ ܹ proteinase, peptidase صǴµ ַ Clostridia, Propionibacterium, Prevotella, Bifidobacterium, Bacteroides شȴ.

̳ ָ ̷ źȭ, ܹ, 濡 峻 ȭ з 麸ٴ ﰢ ҿ ȭ, ؿ ũ Ÿ ִ. ׷ ᱹ ̵ ҵ 峻 پ缺 Ͻ ȭ ְ ̷ ȭ ش ҿ Ȱ ִ Ư ַ Ÿ. 忡 ̼ ȿŰ butyrate ʷϰ ġ ̼ ȴ. źȭ ̴ܹ butyrate ҿ ܹ Ȱ ִ ϰ ȴ.

̴ ϹǷ ɷ ִ Ư (Bacteroides, Alistipes , Bilophila) Ϻ ױ Ȱ ҽǵǴ ҷ 峻 ȭ ִ. äڵ źȭ ̸ ϱ Prevotella, Clostridium clostridioforme, Faecalibacterium prausnitizii źȭ 峻 ָ ̷ ǰ ݴ ̵ 峻 Bacteroides, Bifidobacteria, Enterobacteriaceae species Ҹ ̰ ȴ.

, , , ÿ ð 峻 پ缺 ִµ ̴ ġ ǿ õ پ缺 ũ. ȸ ÿ ַ ̷ ̴ 밳 ̰, źȭ ̼ 븦 Ư¡ ϰ ִµ, ̴ 񼭱 ̿ Bacteroides Prevotella 峻 پ缺 ҽŰ ʷѴ. ݸ ð ̼ źȭ Prevotella, Succinivibrio, Treponema ؼ 峻 ѳ Ÿ. Ư Prevotella źȭ ǰ ̰ Ȯ ÿ ð ̸ ݿϴ ִ. Ƶ 忡 Bifidobacteria еε ϴ HMOs(human milk oligosaccharides) Ƶ ϴ ֱ ̴ ׷ Bifidobaceria 깰 Һ ִ.

Ŀ , ޼ , Ž ¿ Ư 峻 ȭ ִ. ռ ߵ 峻 ȭ polysaccharide (ȿ) ܼ(SCFA, propionate, butyrate, acetate) 縦 Ѵ. SCFA ޵Ǵ ü 10% ϰ ̴. 峻 弼 Ӹ ƴ϶ G Coupled Protein Receptors (GCPR) 忡 Ͽ 漼, ν ΰ ְ Ǵµ, ϰ  鿪 ȰȭŰ ȴ. 峻 漼 ߼ ϰų ߼ ݷ׷ ռ 縦 ϱ⵵ Ѵ. ̵ ȭ, , Һ Ѵ. ̷ ұ 峻 ȭ͵ 谡 ִ. ֽ 峻 ȭ ұ ٽ , 缺 ȯܿ Ǵ Žĵ Űų ½ų ִ ۿϴ Ǽȯ ´.

鿡Լ 峻 ȭ е monosaccharide ϰ Դٰ 峻 ȭ polysaccharide ȿ ϴ ϸ鼭 ⼭ Ǵ ׿ ߰Ǵ ִ. 峻 ѿ κ ϴ پ缺 ҿ Բ Firmiticutes : Bacteroides ź Methanobrevibacter smithii 峻 ȯ濡H2 Ÿ polysaccharide ȿ Ÿ. 鿡Դ 弼 ֿ ޿μ Ҹ butyrate Բ ݷ׷ ռ de novo lipogenesis ۿϿ ü acetate ַ ߰ߵȴ. ׷ ٸ 鿡 ϸ M. smithii ε Ѵٰ ϸ, LAB(Lactic acid bacteria) پ缺 ȭ Lactobacillus L. reuteri Bifidobacterium, escherichia coli ҷ ȴ (Obesogenic species) Blautia hydrogenotrophica, Coprococcus catuss, Eubacterium ventriosim, Ruminococcus broomii, Ruminococus obeum ִ ˷ ִ. 峻 ȭ ⵵ ϴµ HGC(high gene count) οԼ F. prausnitzii, A. muciniphia ׿ ݸ, Bacteroides Ұ ȴ. ݸ LGC(low gene count) 峻 ȭ Ʈ õ ڵ Ǽ Ÿ.

̷ 񸸿 ־ 峻 ۿ ڿ 峻 տ ü鿡 ִ.

phosphotransferase system, źȭ , ۰ ڵ Ǵ ݸ, transcription nucleotide縦 Űϴ Ұ cofactors vitamin ҿ Ҿ Ÿ. ۿ ̾ ϰڴ.
ϸ (dailypharm@dailypharm.com) ٸ
  • μ
  • īī
  • ̽
  • Ʈ
  • 0
ñ
/home/dailypharm/issueData2017/
ǰ
0
͸ǰ | Ǹǰ߾ Ģ
ݱ

Ǹ ͸ , Ǹ ̸ ̵ ˴ϴ. ͸ ʸ ϸ, ͸ մϴ.

ڹ(-ڴϾ-ʱ ) ˵ ϸ ȸ Խ ⡯ ĺ Ʈ ׻ ֻܿ ˴ϴ. ο ø Ϲȸ Խ ĺ ڴϾ ȸ ϴܿ ǽð ˴ϴ.

뺸 ϰ ̵ ̿ Ǵ ֽϴ.

  • ۱ǡΰݱ Ÿ Ǹ ħϴ

    α׷ ϰ , ȳϴ Խù

    Ÿ Ǵ 3 ۱ Ÿ Ǹ ħ Խù

  • ٰ 桤 Ѽϴ Խù

    Ư ̿ ο ν 弳

    Ư 븳 ϴ

    Ȯ ȵ ҹ Ű

    弳 , Ӿ

    Ź, ɿ ˵Ǵ ( û )

    Ư ̳ ü ϴ

    Ư ѼϿ ش ûϴ

    Ư (ֹεϹȣ, ȭ, ּ ) Խϴ

    Ÿ ID Ȥ г ϴ

  • Խ Ư ѵǴ

    ʴ

    翡 ߺ

    κ Ͽ ݺ ϴ 쵵

    Խù,

    Ե Խù

    Խù б

  • û ִ

  • Ÿ

    ʿ伺 ̸

    Ÿ ˵Ǵ 縦

    Ÿ  ڰ ʿϴٰ ǴܵǴ

  • Ȯ

    ۱ڷκ , , ϴ

    Ÿ ʻ ħϰų ϴ

    翡 ̿ (Ÿ ID, йȣ )

  • ̻ Ϻ ׿ ̿ 縦 , Ρ ó ֽϴ.

    õ ̴ ҹ Ǵܵǰų ϸ 񽺿 ٶ ʴٰ ǴܵǴ ġ ϰڽϴ.

    رŸ ϸ ڿ ֽʽÿ. ּҴ dailypharm@dailypharm.comԴϴ.

ֽż ݴ
౹ Ϲݾ Top 100(03)
ǰ Ƚ Ǹűݾ
1 Ÿ̷500mg(10) 23638 33104 101,505,000
2 Ȱť 13391 83427 97,389,700
3 Ǹť 10902 91595 73,069,159
4 ݿ 11997 88325 71,846,700
5 ũũ 4431 4720 52,151,000
6 뽺ī 20g 2332 2418 49,544,700
7 319 12291 44,946,300
8 Ź ĸ(10ĸ) 10732 15961 42,562,800
9 S 676 1227 42,429,350
10 ݴ ť÷ 8546 11210 42,423,060
11 ̰źĸ(60ĸ) 1292 2602 37,202,100
12 ġ 8140 41776 36,792,300
13 öŸ(34) 2501 3833 35,705,600
14 ׶÷ ƮŸ 3353 4312 35,035,660
15 Ʒγΰ̾(120) 657 810 34,246,900
16 ġ̽Ʈġ120g 2388 3282 34,107,490
17 öŸ(40) 2100 2586 34,093,300
18 ٿ 30g 2899 5594 33,943,700
19 (120) 1218 2384 32,914,000
20 ڶ-(40) 1737 3804 28,306,900
21 Ժ 5110 8423 27,914,600
22 Ź 3783 5019 27,081,000
23 ƽŸ 434 825 26,872,500
24 ׶÷ ݵ& Ʈ 1824 2172 25,848,300
25 (10) 8429 12233 25,619,101
26 ȲûɿŹ50ml(õ) 1192 2335 25,361,000
27 ݴ ݵť÷ 5324 6920 25,224,900
28 Ÿ̷500mg(30) 2468 3258 24,699,390
29 Ľõ򿬰10׶ 3091 3369 24,306,500
30 6089 25744 24,196,461
31 Ʒ 3226 7806 24,186,252
32 6̺(30ĸ) 2737 3245 23,701,750
33 ġ̽Ʈġ150g 1401 1754 23,469,900
34 ũ 1907 1963 23,302,401
35 λ絹÷(100) 671 1981 22,752,400
36 ݿ 5552 7933 22,665,600
37 ťýȾ0.5ml*60 1158 1319 22,004,000
38 D-׳ 2074 2207 21,799,902
39 Ľõ򿬰5g 3700 3954 20,580,200
40 뽺ī 10g 1603 1663 20,406,600
41 ӽ÷ 1879 2250 20,176,000
42 öŸ 3232 7567 19,371,321
43 ȲûɿŹ50ml() 1585 3803 19,128,000
44 Ȳûɿȯ() 255 1579 19,058,500
45 ƽƮ(150) 195 351 18,535,100
46 Ÿ̷8ð̾˼ 4493 6574 18,407,000
47 ʽ÷÷ 2748 3217 18,376,001
48 īɾ10g 2552 2817 18,221,600
49 Ʒγΰ(100) 525 1187 18,136,800
50 (10) 2814 3718 18,035,700
51 6̺꿬ĸ(10ĸ) 4711 6546 17,234,600
52 ھ ߽20ml 1500 1754 17,208,900
53 ƽŸ 313 594 16,459,972
54 ݴŰ÷ 3393 4385 15,960,800
55 ̵Ⱦ 14ml 2463 2769 15,949,650
56 ǥȲûɿ 50ml 1061 3758 15,544,646
57 ڷƮ 2mg (Ʈ) 693 1630 15,516,200
58 Ź 2643 3839 15,388,600
59 ѺŸC1000mg 814 2828 15,249,703
60 λ絹÷(270) 194 737 15,225,500
61 밢()(18) 1795 2220 15,094,100
62 ̵Ⱦ 14ml 2416 2576 14,910,600
63 λ絹(100) 491 907 14,826,800
64 ׺ƽĸ 294 546 14,789,500
65 翬ĸ(120ĸ) 372 387 14,722,300
66 Ź̵ 3100 3837 14,720,200
67 Ʈ0.1%й 1182 1495 14,673,700
68 ȭ 4074 18105 14,639,465
69 Ʒ 2856 4634 14,629,300
70 ѽŻ÷(10) 3458 5196 14,582,200
71 ׺ǵ 1246 7135 14,399,712
72 ݴŰ÷ 3107 3696 14,384,750
73 ÷ 3969 4682 14,254,868
74 ƼǪīŸö󽺸 2531 4745 13,924,700
75 ̵Ⱦ׼ 14ml 2151 2411 13,871,800
76 īٿĸ(60ĸ) 299 427 13,498,500
77 ΰ 155 206 13,325,000
78 2480 9352 13,106,010
79 ξ 487 5011 13,096,210
80 ƼǪ Ŀ 1714 3762 13,033,911
81 īɾ 6g 2647 2864 12,758,350
82 10 1610 2720 12,753,338
83 ƽúŰ÷(10) 2340 2566 12,706,610
84 ġĸ(60ĸ) 452 984 12,697,600
85 տ翬ĸ(80ĸ) 349 449 12,559,600
86 Ǫ÷ 3092 4079 12,536,300
87 īڿ;(300) 425 459 12,408,600
88 Ÿ̷ݵ忡 2519 3686 12,349,800
89 2% 120ml 683 707 12,166,600
90 ġĸ(120ĸ) 241 251 12,094,000
91 ȯ 1945 2815 12,000,300
92 Ŭƾ 972 1013 11,992,500
93 ƼǪ Ŀ 1949 4686 11,989,100
94 ݴ ť÷ 2523 3104 11,948,900
95 ǥȲûɿ50ml(õ⺯) 584 1190 11,875,100
96 1100 1463 11,805,800
97 ؽ 1141 1198 11,802,000
98 ڸŰĸ 2134 2516 11,677,500
99 Ⱦ0.5ml 573 659 11,636,000
100 ƮƮŰ& 1615 2330 11,516,140
ü



ͳݽŹϹȣ: 00048 | 2005.09.09 | 2005.09.09 | : | : ȣ
ּ: ı 128 SK V1 GL ƮνƼ A 401ȣ
ȭ : 02-3473-0833 |ѽ : 02-3474-0169 | ûҳ⺸ȣå(å ű)
Contact dailypharm@dailypharm.com for more information
ϸ () ϴ ۱ǹ ˵Ǹ, 縦 ֽϴ.