[8] ȯ ް3
ȯ ̻, 索, , ȣı (ARDS), 帧, Ǻȯ, Ƶ ִٴ ٰŰ Ȯġ ° ̽ 絵 ġ ܿ ƽǸ ƴұ ʹ.
ƽǸ η ġ ȭ ΰ̳ ؿ ġǾǰ̶ ο з ȯŰ ΰ̴. ð 귯 ο ۿ ȿ ȿ ǥǴ ġ ij Ķ ο е 巯鼭 ٽ Ǿ ϴ ִ ̽Ŀ ƹ ̴.
70 ̻ ƽǸ Ȯ Ϻϰ ʾҰ, 1960 Collier ƽǸ νŸ۶ ռ õ Ȱȭ Ѵٴ 1970 ٸ NSAIDs Բ cycloxygenase(COX-1,2) Ѵٴ ˷ ƴ. Ư ̵ϴ ϰ ó ϴ ƽǸ ϱ ̾.
ƽǸ COX-1 PG(Prostaglandin)TX(Thromboxane)ռ Ȱ ߿, , ´. TXA2ռ ظ Ȱȭ ϸ鼭 ̿ ִ Ǽ PGI2(Prostacyclin) ռ ҽŰ ۿ (blood clot) 帧 ְ Ѵ. ƽǸ ۿ Ϻδ 뷮 ٸ ִ. 뷮(81mg) ƽǸ ٸ ߿ ۿ ִµ, ƽǸ 뷮 lipoxins(LXs, 15 epi-LXA4, 15 epi-LXB4) ռ ϱ ̴. ݸ 뷮 ƽǸ LX(lipoxin) ռ ʴ´. LX (anti-inflammatory eicosanoid)μ ߹ (pro-inflammatory eicosanoid) LTB4, PGE2, TXA2鿡 Ѵ.
LXs(lipoxins) ռ ƽǸ ʴ 2 鿡 Ǵ LXs ƽǸ Ǵ ATLs( aspirin-triggered lipoxins, 15 epi-LXA4, 15 epi-LXB4) ٸ LXA4, LXB4̴. ƽǸ acetylation COX-1COX-2 ۿ ϴ θ ˷ Դ. Ǽ Ǽ, ƽǸ COX-2 acetylation ȿҸ AA15Rhydroxyeicosatetaenoic acid(15R-HETE) ȯŰ ϰ ̰ ٱ 5-lipoxygenase(5-LOX) ۿ뿡 epi-LXs ȴ. (epi-)LXA4 ALXR ˷ specific G protein-coupled receptor(GPCR) ۿ Ÿµ, ü MAP-kinasePhospholipase C- (PLC-)-mediated singaling pathway Ȱȭ 鿪 Ѵ. LXPMN(Polymorphonuclear leukocyte) ȭ(chemotaxis), PMNŰ ħ Ǽ PMN Ѵ.
ļ pro-inflammatory M1 phenotype anti-inflammatory M2 phenotype ȯ apoptotic PMN ļۿ ϴµ, ̰ ٷ ƽǸ ó ȸ Ű ٰŰ ȴ. IL-8 , TNF- к ۿ , TGF- Ȱ , Ÿ ۿ Ѵ. ̿ ϴ PGI2(Prostacyclin) NO(nitic oxide) ٸ NSAIDs ƽǸ Ư¡ NO ȴ. ƽǸ NO Ǵ ҽ ϹǷ ȣۿ뿡 ߿ ϰ ȴ.
ڰ ݾ ƽǸ ϰ ٷ LX(lipoxin) , lipid modulator̸ ռ ó LX ް6 AA ϴ (anti-inflammatory eicosanoid)̱ ̴. ⼭ 츮 ˰ ִ . , Ư AA COX ߹(pro-inflammatory eicosanoid)鸸 ǵ ٿ ϴ ˰ ־ ƽǸ Ű ٸ 2 (anti-inflammatory eicosanoid)鵵 ǰ, ư AA Ǵ lipoxinܿ ް3 EPA DHA resolvin, protectin, maresin ϴ Ű Ѵ.
ް6 AA ް3 EPA DHA ۿ뿡 Ǫ 谡 ٷ ̵ ̴. , ȯ ٽ ϴµ ־ ް36 ִ ٰŵ ϳ ǰ ִ.
Lipoxin(LX) resolvin, protectin, maresin Ī SPM(Specialized pro-resolving mediators) ϸ, lipoxygenase, cycloxygenase, cytochrome P450 monooxygenase enzymes ܵ Ǵ ۿ뿡 ȭ(PUFA) Ǿ cell signaling molecules̴.
ռ LX ó ̵ ȿ ü ȰȭǴ Ϳ ִ ռSPM( metabolically resistant SPM analog) Ͽ resolution pharmacology Ǿ μ ϰ ֱ ϴ.
Resolvin(RV) ̸ ü resolution phase interaction products ̴. Dø RV DHA, Eø RV EPAκ Ǹ, n-3 DPA RV ִ. Protectin(PD)Maresin(MaR) DHAn-3 DPAκ ȴ. LXó RVPD ƽǸ Ǵ epi-RV, epi-PD ִ.
cytochrome P450 monooxygenase Ǵ ƽǸ COX2 EPA18 R-HEPE ȯ кǾ ϸ5-LOX Eø RV(RVE1,RVE2) ȴ. ̵ ҽŰ, PMN , ϸ, IL-12 ϸ鼭 ȭŲ. ̴ ٸ PD, MaR鵵 ̴.
̷ SPMs õ ˷ ȯ, Ƽ , ż Ǫ ڰ鿪 ȯ, Ǽ, ưȭ, ɱٰ , 1 2 索, ı, ̸ ġ ġῡ ְ ȴ.
SPMs ް3 EPADHA ް6 AA ʿϴ. ̵κ Ǵ SPMs ٸ ް ִ Ǿ ϴ ̴.