24.03.19 (ȭ) 20:04

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"๰ ִ 峻"
ϸ 2016-11-12 06:14:50
"๰ ִ 峻"
ϸ 2016-11-12 06:14:50
, ƼƮƹ̳ ڷ ãƺ



[1]ι̿ƽ ๰

ǥ ׺ ɹ漼 ɽ ڵ ϴµ Ǵ ๰̴. ׷ 1989 ǥ 翡 Ϲΰ ε ȯ ü (Digoxin reduction products(DRP), Ȱȭ ü)󵵰 36%, 13.7% ̴ ܰ 峻 ϴ ̻ Eggerthella lenta ̿ ü ִٰ ̵ ̻ ȭ 翡 ģٴ ˷ ƴ. case-control study θ̽ Ǵ ƮŬ DPR ҵ Ÿ ̵ ׻ 峻E. lenta ҷ (digoxin toxicity) ִٰ ߴ. ׷ ׻ ϰ ƴ. ׷ Ȯϰ ʾҴ ᱹ 2013 ǥ ڵ ſ Ȱȭ cytochrome-encoding operon E. lentaϺ strain鿡 Ȯεư operon ȰȭŰ cardiac glycoside reductase ΰ (cgr1 cgr2) Ѵٰ ߴ. ׷ ڵ Ȱȭ microbial biomarkersμ õ 迡 ƹ̳ Ư Ƹ operon Ͽ Ȱ Ű ߴ.

Ÿ̷ 귣 ˷ ƼƮƹ̳ θ ǰ ϹǾǰ νĵǰ 翡 Ⱓ ̷ Դ. 캸. 18~64 شǴ 99 ๰ , Һ ü 1000mgƼƮƹ̳ 3ð , 3ð 6ð Һ ü  мߴ. ƼƮƹ̳ õ üμ acetaminophen sulfate(S)acetaminophen glucuronide(G) мߴµ ƼƮƹ̳ ص phase 2 2 conjugation process(O-sulfonationglucuronidation) Ǵ ˷. S/G κ ƼƮƹ̳ ̸ Ÿ ִ ô̱ ̾. ڰ S/G پ缺 ٰŵ p-cresol sulfate 󵵰 Ҵ. ̴ Ư 峻 ̻ Ǵ p-cresol ƼƮƹ̳ human cytosolic sulfotransferase (SULT1A1)̶ ȿҿ μO-sulfonation ϱ p-cresol sulfate(p-cresolO-sulfonationü) 󵵰 ƼƮƹ̳ sulfonation Ͽ ƼƮƹ̳ (acetaminophen toxicity) ߻ϱ ̾. ϸ, p-cresol ϴ 峻 ̻ ƼƮƹ̳ Ÿ ִٴ ̴.

Ų ġ ǰ ִ װ ϻ縶̵ ȿ ȯ 2-sulphamoylacetylphenol ȯ ȴ. ׷ ׻ ó 㿡 ϻ縶̵带 汸 Һ ȯü2-sulphamoylcatylphenol Ұ ƴ. ׸ ٽ 峻 ȸŰ ȯü ־. 迬 8 strain ϻ縶̵ ȯ ߰, Clostridium sporogenes ȯ ũ Ÿٰ ߴ. 峻 ̻ ̵ ȭ ϻ縶̵ 翡 ִ ̴.

峻 ⼺ տ Ʈδϴ ü acetamideN-(2-hydroxyethyl)-oxamic acid ǹǷ ̵ Ǵ Ư Clostridium perfringens رտ Ʈδϴ 簡 Ͽ ๰ ȿ Ҽ ˷ ̴.
L-DOPAHelicobacter pylori Ȱ ִ ݸ 忰ġḦ Ǵ Ļ 峻 ̻ ȿҵ鿡 ฮ Ȱ 5-amino 5-salicylic acid ȯ ๰ Ȱ Ѵ.

ɹٽŸƾ hydroxylation, -oxidation, glutathione conjugation, glucuronidation ġµ 峻 ̻ demethylation, carbon-carbon , , oxidation, dihydroxylation, cyclization ๰ ȿ ҵ 2011 ǥƴ.

峻 ƴ ܺο Ե տ ؼ ๰ Ȱ ִ. Sphingmonas Ibu-2 5 ȿҿ ̺ acid chain ๰ ȿ Ҹ ϴ ִ. ǥ H2 Ƽ 峻 ̻ N-oxide ๰ Ȱ ϴ ˷ ִ. Ȯ Ȯε ƴ 峻 ̻ ȭ ๰ ȿ ִ ϳ ̴. ˷ chloramphenicol, salicylazosulfapridine, carnitine, sorivudine, irinotecan, nitrazepam ִ.

ݱ ַ 峻 ̻ ȿҿ ๰ Ȱ ȭ ̴. ׸ ȿҵ Ethoxyresorufin-O-deethylase (EROD), Glutathione S-transferase A 1/2 (GSTA1/2), Glutathione S-transferase A4(GSTA4), Glutathione S-transferase M1 (GSTM1), Epoxide hydroxylase 1 (EPHX1) enzyme, Epoxide hydroxylase 2 (EPHX2) enzyme, Sulfotransferase 1C2 (SULT1C2) enzyme, Sulfotransferase 1B1 (SULT1B1) enzyme, N-acetyltransferase 1 (NAT1) &N-acetyltransferase 2 (NAT2), Glutathione peroxidase 2 (GPX2) enzyme ִ. ̷ 峻 ̻ ๰ ȭ reduction, hydrolysis, dihydroxylation, acetylation, deacetylation, proteolysis, deconjugation, deglycosylation , پ ๰ Ȱ , ģ. ݱ 30 ̻ ๰鿡 Ͱ , 峻 ̻ ๰ ൿп ̴.

翡 ̼ ϴ 鿡 ȣϴ ˷ ִ. ׸ Ʈΰ ׷ϴ. 峻 ̻ Ʈΰ 尣ȯ Ȱ ٽɿ Ѵ. 尣ȯ 󿡼 Ʈΰ decojugation Ʈΰ ǹǷ Ȱ ̰ ȴ. 迬 ϸ ׻ 뺯 Ʈΰ 󵵴 ݸ, Һ ߴ. ̼ 쵵 Դ. 峻 ̻ ȭ Ʈΰ 峻 ̴. 峻 ̻ 2-methoxy esterone C17 oxireduction C2 demethylation Ȱ ȯ, ๰ ȿ .

NSAIIDs εŸ ȭ ջ ʷϰ, (glycocalyx layer) Ѵ. ̷ surfactant-like particles (SLP) brush border membranes (BBM) glycosylation ȭ 峻 (translocation) ϰ ȯ ִ. ̷ 峻 ȯ ȭ ๰ ȭ ̾ 2 پ ๰ Ȱ, , ൿ ȭ ұ ߻Ѵ.

Proton pump inhibitor pH ½ 峻 ȣ⼺ ⼺ ʷϰ ظ 뼺 ̵ ߻ ִ. ๰ , 2 ȯ ߻ ̻ ͵ .

ֱ pilot study 峻 ̻ Ÿũθ ൿ ȭ ִ ƴ. Ÿũθ ġ(therapeutic index) ⿡ 뷮 ſ ߿ Ǵ ๰ ϳ̴. ȯ 19 뺯 ü м ̵ 뺯 Faecalibacterium prausnitzii Ÿũθ 뷮 Ÿ. ǰ 峻 ȯ濡 ⿩ϴ ַ ˷ ̷ ๰ 翡 ִ.
ϸ (dailypharm@dailypharm.com) ٸ
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/home/dailypharm/issueData2017/
౹ Ϲݾ Top 100(03)
ǰ Ƚ Ǹűݾ
1 Ÿ̷500mg(10) 23638 33104 101,505,000
2 Ȱť 13391 83427 97,389,700
3 Ǹť 10902 91595 73,069,159
4 ݿ 11997 88325 71,846,700
5 ũũ 4431 4720 52,151,000
6 뽺ī 20g 2332 2418 49,544,700
7 319 12291 44,946,300
8 Ź ĸ(10ĸ) 10732 15961 42,562,800
9 S 676 1227 42,429,350
10 ݴ ť÷ 8546 11210 42,423,060
11 ̰źĸ(60ĸ) 1292 2602 37,202,100
12 ġ 8140 41776 36,792,300
13 öŸ(34) 2501 3833 35,705,600
14 ׶÷ ƮŸ 3353 4312 35,035,660
15 Ʒγΰ̾(120) 657 810 34,246,900
16 ġ̽Ʈġ120g 2388 3282 34,107,490
17 öŸ(40) 2100 2586 34,093,300
18 ٿ 30g 2899 5594 33,943,700
19 (120) 1218 2384 32,914,000
20 ڶ-(40) 1737 3804 28,306,900
21 Ժ 5110 8423 27,914,600
22 Ź 3783 5019 27,081,000
23 ƽŸ 434 825 26,872,500
24 ׶÷ ݵ& Ʈ 1824 2172 25,848,300
25 (10) 8429 12233 25,619,101
26 ȲûɿŹ50ml(õ) 1192 2335 25,361,000
27 ݴ ݵť÷ 5324 6920 25,224,900
28 Ÿ̷500mg(30) 2468 3258 24,699,390
29 Ľõ򿬰10׶ 3091 3369 24,306,500
30 6089 25744 24,196,461
31 Ʒ 3226 7806 24,186,252
32 6̺(30ĸ) 2737 3245 23,701,750
33 ġ̽Ʈġ150g 1401 1754 23,469,900
34 ũ 1907 1963 23,302,401
35 λ絹÷(100) 671 1981 22,752,400
36 ݿ 5552 7933 22,665,600
37 ťýȾ0.5ml*60 1158 1319 22,004,000
38 D-׳ 2074 2207 21,799,902
39 Ľõ򿬰5g 3700 3954 20,580,200
40 뽺ī 10g 1603 1663 20,406,600
41 ӽ÷ 1879 2250 20,176,000
42 öŸ 3232 7567 19,371,321
43 ȲûɿŹ50ml() 1585 3803 19,128,000
44 Ȳûɿȯ() 255 1579 19,058,500
45 ƽƮ(150) 195 351 18,535,100
46 Ÿ̷8ð̾˼ 4493 6574 18,407,000
47 ʽ÷÷ 2748 3217 18,376,001
48 īɾ10g 2552 2817 18,221,600
49 Ʒγΰ(100) 525 1187 18,136,800
50 (10) 2814 3718 18,035,700
51 6̺꿬ĸ(10ĸ) 4711 6546 17,234,600
52 ھ ߽20ml 1500 1754 17,208,900
53 ƽŸ 313 594 16,459,972
54 ݴŰ÷ 3393 4385 15,960,800
55 ̵Ⱦ 14ml 2463 2769 15,949,650
56 ǥȲûɿ 50ml 1061 3758 15,544,646
57 ڷƮ 2mg (Ʈ) 693 1630 15,516,200
58 Ź 2643 3839 15,388,600
59 ѺŸC1000mg 814 2828 15,249,703
60 λ絹÷(270) 194 737 15,225,500
61 밢()(18) 1795 2220 15,094,100
62 ̵Ⱦ 14ml 2416 2576 14,910,600
63 λ絹(100) 491 907 14,826,800
64 ׺ƽĸ 294 546 14,789,500
65 翬ĸ(120ĸ) 372 387 14,722,300
66 Ź̵ 3100 3837 14,720,200
67 Ʈ0.1%й 1182 1495 14,673,700
68 ȭ 4074 18105 14,639,465
69 Ʒ 2856 4634 14,629,300
70 ѽŻ÷(10) 3458 5196 14,582,200
71 ׺ǵ 1246 7135 14,399,712
72 ݴŰ÷ 3107 3696 14,384,750
73 ÷ 3969 4682 14,254,868
74 ƼǪīŸö󽺸 2531 4745 13,924,700
75 ̵Ⱦ׼ 14ml 2151 2411 13,871,800
76 īٿĸ(60ĸ) 299 427 13,498,500
77 ΰ 155 206 13,325,000
78 2480 9352 13,106,010
79 ξ 487 5011 13,096,210
80 ƼǪ Ŀ 1714 3762 13,033,911
81 īɾ 6g 2647 2864 12,758,350
82 10 1610 2720 12,753,338
83 ƽúŰ÷(10) 2340 2566 12,706,610
84 ġĸ(60ĸ) 452 984 12,697,600
85 տ翬ĸ(80ĸ) 349 449 12,559,600
86 Ǫ÷ 3092 4079 12,536,300
87 īڿ;(300) 425 459 12,408,600
88 Ÿ̷ݵ忡 2519 3686 12,349,800
89 2% 120ml 683 707 12,166,600
90 ġĸ(120ĸ) 241 251 12,094,000
91 ȯ 1945 2815 12,000,300
92 Ŭƾ 972 1013 11,992,500
93 ƼǪ Ŀ 1949 4686 11,989,100
94 ݴ ť÷ 2523 3104 11,948,900
95 ǥȲûɿ50ml(õ⺯) 584 1190 11,875,100
96 1100 1463 11,805,800
97 ؽ 1141 1198 11,802,000
98 ڸŰĸ 2134 2516 11,677,500
99 Ⱦ0.5ml 573 659 11,636,000
100 ƮƮŰ& 1615 2330 11,516,140
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