ȭ 'а' ߹ ¹ ߾ ް ֵ ó 'Dr. Ka Young Chung' 'Protein Structure Lab.' Ǿ ߴ.
۳ 12 ũ , հб ڿķ۽ а 5 (lab) ( پִ) 湮 ǻ Ϳ ġ鸸 ǰ ־. ¦, ̼Ұ ־.
״ ġ ҳó ݾ߰ " ƹ͵ " ſ ̾ ǥ . Ŀǿ ġ ũ ξ ϴ ȸ 鸸ŭ. а . ڰ ϴ ̾, ãƺ . ٸ ȥ 츲ó Ȱִ dz Ⱑ 귶.
97й հ 20 ڴ. GPCR ̽ ߰ ִ ó ݷϰ 䵿ġ ִ. ״ ȭ ι̾. ã д ڵ ȭ ƴ.
2012 10 뺧 ƿ ״ Ͼ ȿ ȭ ι̾. , ڿ ̾ ںī Ǵ 'Gܹ ռü(GPCR•G-Protein Coupled Receptors) ۵' 뺧 ȭл ұ ̴. ںī ʴ.
״ 2012 3 հ 뿡 ϱ 2008 3Ⱓ ڻ (ϸ Ȥ ) ںī ǿ ߴ. 2011 ںī Ʒ Rasmussen ( ) GPCR G-protein ü 2 м ó ϸ鼭 ָ ڷ ö.
ںī ״ հ뿡 9 ѱ ϴ NRF ںī 2 GPCR GPER Ըϱ ϰ ִ. ϸ Ǿ 2 3 ް ִ.
״ ߴ. μ ٸ ڵ " "̶ ߴ. "θ ʰ, ڴ" ߴ. Ȯϰ ȴ.
״ "ڷμ G-Protein ȣ "̶ ߴ.
ڷμ " , Ű ʹ" ߴ.
Ϻϰ ǰ ̾߱⸦ .
2012 뺧ȭл ̾ ںī ڷμ, ڷμ ָ Ҵ հ ġ .
켱 øƮ ģٴ γ ֽø ڽϴ. , ϴϱ. GPCR ?
". ؾ ұ? GPCR 'Gܹ ü(GPCR•G-Protein Coupled Receptors)'μ Ѵٰ ִµ䡦."
װ 츮 ִ ?
" ־. 츮 ϴ ̾߱ ؾ߰ھ. 뷫 100 ִٰ ϴµ, ̰ մϴ. ü, ļ ̾߱ ְ, , , ̰ پϰ ϴ ϵ ٸϴ. Ȱ ִµ, GPCR ȣ ڱ, ȣ, ȭй ϴ Ȥ ̶ ֽϴ."
žళ ε, GPCR Ǿǰ ߰ ִ ǰ? ִٸ ϴ κ ּ.
", մϴ. ˷ . 츮 ȿ Ÿ(Histamine) þ äⰡ ȲԴϴ. ̶ Ǿǰ 䳪(fexofenadine) ϴ . 䳪 ִ GPCR histamine H1 ü ε Ʈ پ Ÿ ü ϵ ν, ٽ ä⸦ ϴ 2 ϵ Ÿ ȣ ϴ ̴ϴ. GPCR ó 䳪(Ǿǰ)̳ Ÿ ٱ̳ (Ligands) ϰ 鿩 ܹ ۵ϵ ϴ ϴ ̴ϴ."
GPCR Ȱ ? , 1̳Ĵ ̴ϴ.
"ƴմϴ. ݱ ٷδ 뷫 800 ֽϴ. ٸ ."
GPCR Ÿ Ǿǰ Ȳ .
"ȭǰ 40% GPCR Ÿ ϰ ֽϴ."
GPCR Ÿ ֱٵ GPCR ߰ſ .
"ũ ݱ ϰ ȿ ִ ã Ǿǰ . GPCR ۵ GPCR ˰Ե ."
GPCR Ըϰ ۵ ٴ žళ߿ ǹ̰ ִ ?
"Ʊ 帰 Ǿǰ 40% GPCR G ܹ ܹ(G-protein) ȣ 2 Ȱ ȭϰų ϴ ϰ ˴ϴ. ٽ ȿ Ÿ ˰ ȿ Ǿǰ Դϴ. ִ 쵵 GPCR , յ ִ ϸ ȿ Űų ۿ ̶ մϴ."
ù ڵ. ʰ źź ϴ ǥ ߴ.
ɻ .
"GPCR ܹ . '/ ġȯ м ' (Hydrogne/Deuterium Exchange Mass Spectrometry) ֽϴ."
ȸ鵵 žళ߿ ϰ ִµ, ӻ .
"̿ ùз ϴ ȸ ̿ Ǿǰ ùз ܹ Ը ְ, ȸ簡 ϴ Ǿǰ GPCR ϴ ְھ. ̶ ܱⰣ ÷ ü¿ ִ ִٴ ̴ϴ. ִ ƴϿ. ϰ ִ ϱ ġ ʰŵ."
칮ε. ð Ƴ?
"б ;. ȸ ̾. п ڵ . ɵ ۿ ."
ڻ ܽŴ ?
", ̷ ֱ ϰ . 츮 ǹ Ⱑ Ϲݾƿ. ð 帣 , ϰڱ ;. ۵ ٴ ǵ ˰ Ʊ. п ڿ ̽ ư߰ڴٴ . л鵵 Ű ƴ ƴ϶ ʺ ذ ɷ ⸣ ϴ ͵ λ̾."
ںī ̾? ̼?
"ڻ縦 ġ 뿡 ںī Ʒ ڻ () ߾. GPCR Թϰ ͵ ̿. о߸ ϸ ִ ֽð ñô. ̼. ּ̽ϴ. ð ϰǰ ϼ̾. 鿡 ϴ."
̸鼭 ÿ ε, 濡 ɰ ?
" ִٴ ŷ̿. ڴ ڱ θ ݾƿ. ϰ µ ǹ̸ ã´ٰ ұ? ڴ 縦 Ű ű⼭ ĻǴ ̿ ־. 2 . . п Ű ߿ ? ⸦ Ҹմϴ."
ڷμ ǥ ?
"GPCRκ 2 G-Protein () ȣ ϸ俬ϰ ̴ϴ. ϻ ǥ Դϴ. о ġϰŵ."
2012 뺧 2 17 ǥϼ̴µ, ӿ ô ƴѰ?
". ϰ , ġ ŭ Դϴ. ٰ Ǵ ƴϴ Ѵ, ̷ ϰ ־."
ںī Ե ΰ? ϴ ƽװ Դϴ.
", Կ Űó. ڵ鰣 ݵ ־. ٽɿ ȵ˴ϴ. 꿡 ݸ ij ."
ϰ ֳ.
"л 5 1 6 ־. л 3, ڻ 1, ڻ 1̿. Ե鿡 л鿡 100 1 ϸ ϴ° 鼭 ⸦ οϰ ־. ں Ǹ ڸ 缺 ;."
̱ ִ 8Ⱓ ŷ , ǥ ϴ հ뿡 ڸ ŷ Ѵ. Ĺ ʿ ִ. ǿ غ¼ ̴.