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Ÿ GI-101+ŰƮ ...ȭ
2021-06-01 06:00:48
Ÿ GI-101+ŰƮ ...ȭ
2021-06-01 06:00:48
[¡ K-̿] ȣ ̳뺣̼ ǥ

Ϲݱ 强Ưʻ پ ӻ

ӻ MSD 'KEYNOTE' ȣ οȿ ӻ


߹: ¡ K-̿
:
߿ :
⿬: ȣ ̳뺣̼ ǥ


[׸Ʈ] ۷ι ٴ ̿ 캸 '¡ K-̿' ðԴϴ. ڽ Ǵ ̳뺣̼ ˾ƺٵ. ȣ ǥ̻ ֽϴ. ǥ, ȳϼ?

[ ] GI-101 CD80 IL2 ÿ Ÿ 鿪 ȿ 鿪 ȿ ÿ Ÿ ܹԴϴ. 鿪 ȿ ϼ ִ CD80 ؼ T CTLA-4 ϰ ν ϴ ǵ. CTLA-4 ϴ 鿪׾ '' ѵ ٸ ִٸ?

[ȣ ǥ] ̴ T ϴ CTLA-4 ϴ üԴϴ. GI-101 CD80 CD28 T ִ ñ׳η 鿪 Ȱȭ ְ ˴ϴ. ڼ 帮 ̿ ϴ CD80 پ ִ κԴϴ. ̴ ſ ϰ ִ T (Treg cell) ְ ˴ϴ. 忰 ߻ ִ ֽϴ.

ݸ GI-101 Treg cell ʰ, ֽϴ. ߻ IL-2 ƴ϶ IL-2 ü̱ Treg cell Ǵ IL-2 ü(receptor) Ŀ ϰ յǵ ε ֽϴ. CD80 κ 鿪( ) ۿ ϰ, IL-2 ü κ ׾ ȿ ̴ 鿪 Ȱȭ(activation)ϵ ۵մϴ. IL-2 κ ڿؼ(NK cell) ۵ T (effect T cell) ĽŰ, Treg cell Ȱȭ ʴ ϰ ˴ϴ.

[ ] . IL-2 鿪 Ȱ ȿ ۿ ִ ˰ ֽϴ. GI-101 ۿ  ּȭϰ ִ ñմϴ.

[ ǥ] ֱ Fc IL-2 캸, GI-101 뷮 ̰ ϰ Ǿϴ. ׷ GI-101 IL-2 ξ Ÿϴ. CD80 IL-2 տ پִٺ ַ 鿪 ǥϰ ǰ, ִ Ǽ  ʱ Դϴ.

Ϲ ī IL-2 ǥȭ ƴٺ ſ ִ IL-2 ü ɼ , ̴ ̾ϴ. GI-101 CTLA-4 CD28 ǥν 鿪 ɼ پ ˰ Ǿϴ. ̿ ۷ι 鵵 IL-2 ü ๰μ ָϰ Ǿϴ.

GI-101 IL-2 ƹ̳ Ϻ IL-2 üԴϴ. IL-2 ߻ 2 ƹ̳ ü IL-2 ߻ ߻Ǵ ı 輺 ߽ϴ.

Fc κ ΰ IgG4 ̷ ADCC(ü Ű ) ظ ̹Ƿ ٸ IgG1 ü մܹ ۿ ǰ ֽϴ.

[ ] GI-101 ü ÷ 'GI-SMART' ƽϴ. GI-SMART Ư¡ ֽŴٸ?

[ ǥ] ϴ ε մܹ, ư մܹԴϴ. ̴ܹ 꿡 ֽϴ. 300 10 Ұմϴ. ư ̵ ߡ ܹ ϴ ȭ ƽϴ.

̸ ذϱ Ŀ ȭŰ ߽ϴ. κ ܹ 꿡 ߿ ϱ Դϴ. Fcٵ پ Ŀ ũ ܹ Ŀ , Fcٵ ν 꼺 Ȯ ֵ ϴ GI-SMART ٽԴϴ.

[ ] GI-101 ߱ ɽþ ư MSDʹ 鿪׾ 'ŰƮ' ӻ ϰ ֽϴ. ŰƮٰ PD-1 迭 鿪ε, ɼ  Ű?

[ ǥ] ŰƮ ܵ PD-L1 ϴ ȯڿ 20~30%, ׷ ȯڴ 10% ϴ. ׷ٺ ŰƮٿ 鿪׾ ܵٴ ϰ ֽϴ.

鿪׾ ֱ ް ִ κ 鿪 ֱ(cancer-immunity cycle)Դϴ. ̴ 鿪 ϼ ϱ ܰ谡 ִٴ ܼƮ ٸ ܰ踦 Ȱȭ 鿪 ȿ ϼ ֵ մϴ.

GI-101 ϴ CD80 κ -鿪ֱ 鿪 ʱ Ȱȭ ܰ迡 ۿ ʱ⿡ ׾ T Ȱȭ ֵ ְ, IL-2 κ ׾ 鿪 ֵ մϴ. ׸ ŰƮٿ PD-(L)1迭 鿪 鿪ֱ Ĺݿ شϴ 鿪 ν Ȱȭ ֵ մϴ.

鿪 ֱ ʱ ı ܰ迡 ۿν ๰ ̶ ΰȭ 콺 ߽ϴ. MSD ָ ӻ ܰ ӿ ұϰ ŰƮٸ ϴ ӻ Բ ԵǾ KEYNOTE-B59 ȣ ް Ǿϴ. ӻ MSD ӻ ϸ ְ Ǿϴ.

[ ] ׷ ŰƮ ü ӻ ΰ  dz?

[ ǥ] ӻ ߿ѵ. ο ʱ⿡ ȴٰ մϴ. ̹ MSD 20~30 ȸǸ ϼ߽ϴ.

ӻ (Adaptive) (Seamless) ӻ 1~2 ÿ ϰ ˴ϴ. 14 400 ȯڵ GI-101 ܵ , ༺ ׾ȿ ϰ ˴ϴ.

ܵ 2 뷮 ϰ, ̸ ŰƮٿ ϱ 뷮 ã ˴ϴ. ȿ ӻ MSD Ͽ ŰƮ ȿ Ǵ 7 ߽ϴ.

׹ۿ (VEGFR TKI) ̹ ӻ󿡼 غ մϴ. Ȱȭ T NK  ؼ ȭ ʿѵ VEGFR TKI ̷ մϴ. GI-101 VEGFR TKI ν Ȱȭ ׾ 鿪 ϼ ħ մϴ.

Ҿ ġῡ ־ ׿ Ǵ ߿մϴ. ׷ 缱 ϴ ӻ ȹ ԵǾ ֽϴ

ٺ Ҹ Ͻ ִµ ӻ Ȯؼ ߰ ȯڵ ϰ, ӻ ϴ ӻ ȿ Ȯ ˴ϴ. GI-101 ӻ ùȯ Ϲݱ Ǿ ֽϴ.

[ ] ̳뺣̼ ݱ 强 Ư ϰ ֽϴ. 3 A ޾Ҵµ Ưʻ ƴ 强Ưʻ ñմϴ. ϴ ַ  ̰ dz?

[ ǥ] ӻ ܰ迡 ɽþ Ѿ࿡ 2 ߽ϴ. Ưʻ ϴµ, ӻ ̴ܰٺ 򰡹ޱ ָ κ ־ϴ. ϼ 鿡 1~2 ӻ迡 ؾ߸ ֱ Դϴ. ְ Ǹ Ͻ 强 ٰ Ǵ߰, 3 ȸ 强Ưʻ ϰ ƽϴ.

ӻ ܰ迡 ϰ ӻ ʱ ۷ι ؼ ϴ ŷ ̶ ϰ ֽϴ.

[ ] ñ ü ŸӶ  dz?

[ ǥ] ó ̹ 彺 Ծµ 强 Ưʹ ٰ մϴ. Ⱓ 1~3 ̵ ͼ Ϲݱ ~ܿ ñⰡ ̶ Դϴ.

κ ڱ ӻ迡 80% Ǵµ ۷ι ѱ , GI-101 ϴ ۷ι 簡 ٺ ߰ ۷ι ٸ ΰ ӻ ȹԴϴ. ü 1000 Ը ӻ մϴ. ӻ ȯ 1 2Ⱓ 2 Ե ϸ 2000 ڱ ҿ Դϴ.

[ ] , ǥ ̳뺣̼ پ Ȱ ˴ϴ.

[Ŭ¡ Ʈ] '¡ K-̿' غ Դϴ. ҽ ð ãƺ˰ڽϴ.
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ֽż ݴ
ٺ Ϲݾ ǸŰ (2024 04)
౹ 31
ǰ ְ
ѽŻ÷(10) 3,500 2,500 1,000 3,009
޾(100) 24,000 23,000 1,000 23,200
Ʒγΰ(100) 30,000 28,000 2,000 28,500
īɾ(10g) 7,000 6,000 1,000 6,559
Ľõ򿬰(5g) 5,000 4,500 500 5,138
Ź(4) 5,000 4,000 1,000 4,438
ڶ(20) 6,000 6,000 0 6,000
(10) 6,000 4,500 1,500 5,071
Ժ(10) 4,000 3,500 500 3,712
ڱ׸(20) 5,000 4,500 500 4,717
ť(10) 3,000 2,500 500 2,990
Ȱť(1) 1,200 900 300 1,182
Ǯɾ(3.3ml) 26,000 23,000 3,000 24,250
޵𿬰(10g) 7,000 5,900 1,100 6,289
öŸ(34) 13,000 11,000 2,000 11,866
뽺ī(20g) 22,000 18,000 4,000 20,184
ġ(1) 1,000 1,000 0 1,000
ӽ÷(21) 10,000 8,500 1,500 9,205
ͺ(10) 3,500 3,000 500 3,196
ݿ(1ڽ) 3,000 3,000 0 3,000
׶÷糪ƮŸ(6) 8,000 7,000 1,000 7,524
߽Ÿ(120) 70,000 50,000 20,000 60,385
Źĸ(10ĸ) 3,000 2,000 1,000 2,989
Ÿ̾(120) 60,000 50,000 10,000 51,538
տ(60ĸ) 29,000 25,000 4,000 27,600
Ÿ̷ER(6) 3,000 2,500 500 2,750
ٿ(30g) 12,000 9,000 3,000 11,444
(120) 25,000 22,000 3,000 24,991
Ʒ(6) 4,000 3,000 1,000 3,262
ǽõĸ(270ĸ) 110,000 110,000 0 110,000
B(120) 70,000 70,000 0 70,000
׳(10) 3,000 2,500 500 2,778
6̺(10) 3,000 3,000 0 3,000
(60) 230,000 220,000 10,000 223,333
Ⱦ 12,000 10,000 2,000 10,143
̰źĸ(60ĸ) 35,000 30,000 5,000 33,231
Ųť(20) 5,500 4,500 1,000 4,903
λ絹÷(100) 35,000 32,000 3,000 33,297
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