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Dailypharm

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ѹ 'Ƽ', ȯ ȭ 'ΰ'
Ȱ 2018-10-01 06:30:42
ѹ 'Ƽ', ȯ ȭ 'ΰ'
Ȱ 2018-10-01 06:30:42
[DP] ȸ ǥ ORR 15%p ҡ1ġ پ õ 尡ġ



ѹ̾ǰ 'Ƽ' ӻ ߰м ΰ ȴ. ѹ̾ǰ Ʈʻ Ʈ мȸ Ƽ ȯ ġ ߴ. ο 밨 Ծ Ѱ ޸ Ʈ ְ Ѵ ġ ߴ.

ϴ ġ , EGFR HER2 20 ̸ Ȱ ɼ ȮεǸ鼭 ġ ٴ 밨 ȴ. Ƽ ѹ̾ǰ 2015 Ʈ pan-HER2 ׾.

Ƽ 2 ߰м , EGFR 58%43%

Ʈ ĸƼ 24(ð) ȸ(WCLC 2018) Ƽ 2ӻ ߰м ǥߴ. ̹ ʹ EGFR HER2 (exon) 20 ̸ Ҽ(NSCLC) ȯ ӻ󿬱 ִ Ը. ϴ ġ ȯ ׷ ̶ аκ ޾Ҵ.

׷ 忡 Ƽ 븦 ߴٴ 򰡰 ´. EGFR 20 Ҽ ȯ 50 м Ե 44 Ƽ (ORR) 43%. 5 ʷ Ϳ Ȯε (58%) 15%p ̴.

  EGFR 20 ȯڿ Ƽ (ó: Ʈ, WCLC 2018 ǥڷ)

4 ó޵(Nature Medicine 2018;24:638-646) Ϳ Ŀ. åӿ ػ罺Ǵ ̸(John Heymach) (MDشϼ εΰξ а) " ó ORR 20~30% ù ȯ 11 ORR 64% ġ Ÿ´. 6.5 PFS(Ⱓ) ߰ ȿ 밡 ſ ũ" ִ.

̸ 1 ȸ(WCLC 2017) "EGFR Ҽ ȯ 11 8(73%) Ƽտ κй(PR) ̻ Ÿ´" ǥߴ.

  Ƽ ӻǥ Ʈ ְ (ó: ̳)

Ƽ ҿ Ǹ ӻ ǥ Ʈ ְ ݿƴ. Ƽ ORR 43% ǥ 24 Ʈ ְ 16.52޷ 帶ߴ. ŷ(21, 21.36޷) 21.7% . ȸ ǥ յΰ ӻ 밨 ְ ߴ 8 27(24.82޷) ؼ 33.4% ϶ ġ.

̱ ü ŷ(Seeking Alpha) "Ʈ簡 ׾ġῡ ߴ EGFR 20 Ҽ ȯڸ Ƽ ӻȿ ϴ 2ӻ WCLC 2018 ȸ ǥ ְ ޶ߴ. 4 AACR 2018 ȸ 64%, 58% ǥƴ Ƽ ֽ 43% ƴ" ߴ.

ٸ ʷ Ϳ Ȯε Ȯ(Unconfirmed) ̾ ǥ ޵ Ȯ(confirmed) ܼ ϴ ƴٴ ѹ̾ǰ ̴. Ȯ ȭ ϸ 45% 43% 2%p ҿ ģ.

߱ ġ 19% ̸" "

Ƽ ֽ ӻ ƴϴ. 24 ǥ Ƽ Germline T790M 20 (insertion) ȯڵ 55% κй(PR) . Ⱓ(PFS) ߰ 5.5 ʷ (5.6) ̴.

Ƽ ġ ƽ, ǥġ پٴ ҷ Ѵ.

̷(Ƽ), Ÿ(Ƽ) EGFR 20 Ҽ ȯڿ ǥġ 8% ̸ ˷. 2ġ ǥؿ ǰǴ Ź PD-1, PD-L1 19% ̸ Ұϴ. HER2 20 ȯ Ȳε, ׶Ƽ(neratinib), Ʈ(Ƽ), (ڹƼ), ŸĿ(Ƽ) 11.9% ƴ. HER2 20 ȯڿ Ƽ ĺ 55% Ÿ ü-๰ü(ADC) ij϶(Ʈָź) .

  TKI ġ(ó: Ʈ, WCLC 2018 ǥڷ)

ó ġ ڵ ÷ƼѰ ׾(86%) TKI(34%), PD-1, PD-L1 (54%) ġ , 43% ġ м ǰ ִ.

̸ "EGFR ȯڿ 1,2 TKI 3%, ΰ ٰ ˷ 20 (763insFQEA) ϴ 8% Ұϴ. Ⱓ ߾Ӱ 2 "̶ "Ƽ ũⰡ ۰ Ư п غϰ ӻȰ Ÿ" ߴ.

̸ 19 EGFR ȯڵ ġḦ ̴. 6 ๰ 1 ̻ ߴ.

߱ 尡ġ 1ġ ɼ Ȯ õ

Ƽտ 븦 ɸ Ǵٸ Ҵ Ȯ ɼ̴. ó HER2 20 Ҽ ȯ Ϳ , ʱ 50%, Ⱓ ߰ 5.1 ƴ. , Ư ʰ, EGFR HER2 20 ̸ پ Ȱ ûѴ.

ȸ ǥڷῡ EGFR HER2 20 ̴ Ҽϰ ܿ 汤, ΰξ, ĵ, , ĵ, Ҿ پ ȴ. ̱ ü Ҽ EGFR HER2 20 ̸ ϴ ȯں 3.6%(7700) ǰ ִ. ٸ EGFR HER2 20 ߻󵵴 0.6%(8400) ˷.

  HER2 20 ȯڿ Ƽ (ó: Ʈ, WCLC 2018 ǥڷ)

Ƽ 2015 پ ӻ ϸ鼭 ġ ִ. 11 Ҽ EGFR ̿ HER2 20 ̷ Ȯ 2ӻ ߰, ʿ ȯڸ Ƽհ ij϶(T-DM1) ϴ ӻ ߴ. ֱٿ EGFR HER2 20 Ҽ ȯڿ 1ġ ɼ ϱ Ȯ ߴٰ ִ.

׾ ȿ ŭ̳ ߿ ̻ Ȯε ´. ߰ м ü ȯ 56%(63 35) 3/4 ̻ ̻ ȣߴ. (34.9%), (17.5%), (9.5%) ƴ. ̻ 뷮 16mg ȯڴ 60%(38), ġḦ ߴ ȯڴ 3%(2).

̸ "EGFR Ȯε ̾. ̹ ߰м EGFR HER2 20 ȯڿ Ƽ 2ӻ ϰ, 1ġ ȣƮ ߰ߴ" "EGFR HER2 20 Ҽ ȯڸ ο ɼ Ѵ" ߴ.
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ٺ Ϲݾ ǸŰ (2024 05)
౹ 71
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ѽŻ÷(10) 3,500 2,300 1,200 3,028
޾(100) 25,000 22,000 3,000 23,304
Ʒγΰ(100) 30,000 27,000 3,000 29,237
īɾ(10g) 8,000 5,500 2,500 6,472
Ľõ򿬰(5g) 5,500 4,000 1,500 5,035
Ź(4) 5,000 3,500 1,500 4,449
ڶ(20) 7,000 5,800 1,200 6,433
(10) 6,000 4,000 2,000 4,914
Ժ(10) 4,000 3,000 1,000 3,543
ڱ׸(20) 5,000 3,800 1,200 4,622
ť(10) 3,500 2,300 1,200 2,828
Ȱť(1) 1,200 1,000 200 1,140
Ǯɾ(3.3ml) 25,000 22,000 3,000 24,214
޵𿬰(10g) 7,000 5,000 2,000 6,162
öŸ(34) 13,000 10,000 3,000 12,089
뽺ī(20g) 22,000 18,000 4,000 20,358
ġ(1) 1,100 1,000 100 1,000
ӽ÷(21) 10,000 7,500 2,500 8,998
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λ絹÷(100) 37,000 29,000 8,000 31,878
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