24.05.06 () 03:52

Dailypharm

X
ɴ, 뼭 'Ƽ' ๰ ŷ
Ȱ 2019-09-11 06:00:48
ɴ, 뼭 'Ƽ' ๰ ŷ
Ȱ 2019-09-11 06:00:48

[DP] ȸ 'TAK-788' 1/2ӻ ߰м ǥ

ѹ Ƽհ ۿǥ ... Ȯ ַ

[ϸ=Ȱ ] ѹ̾ǰ ׾Ͻž 'Ƽ' ߼ӵ  ๰ ŷ¾ʿ . Ƽ EGFR (Exon) 20 Ҽ(NSCLC) ȯ 1/2ӻ ȸ ޾ Ұϸ鼭 ӻ ȭ ̴.

ߴɴ, TAK-788 2ӻ ߰ ǥ

ɴٴ 8(ð) ȸ(WCLC 2019) ǿ žĺ 'TAK-788' 1/2ӻ ǥߴ. ġ ִ ༺ Ҽ(NSCLC) ȯ TAK-788 Ȱ 1/2ӻ ߰ м. ɴٴ 6 ̱ӻȸ(ASCO 2019) ͸ ִ.

ǥ 1ȸ ̻ 򰡸 26 14 RECIST v1.1 κй(PR) . ְ (ORR) 54% ȴ(95% CI: 33.4%–73.4%). 12 9 ̻ (SD), 1 (PD) · ư, 2 򰡰 Ұ 迡 ܵƴ.

  ASCO 2019 ȸ Ұƴ TAK-788 2ӻ ߰м

PR 14 7 ӻ2 뷮(RP2D) TAK-788 160mg 1 1ȸ Ȯεȴ.

๰ ̻(TEAE) (85%), (43%), (41%), (30%), Ŀ尨(28%), (22%) ˷ EGFR ƼνŰ(TKI) ̻ ߴ. 21.7% ̻ 뷮 ϰ, 10.9% ߴ Ÿ.

" 20 ̸ Ҽ ȯڿ TAK-788 Ȱȿ . ٸ EGFR TKI ϰ Ÿ´" ȴ.

Ƽհ ۿ ...EGFR ġȿ ַ

TAK-788 ɴٰ ̱ ȸ зϾĸƼ EGFR/HER2 . ѹ̾ǰ 2015 ƮĸƼ 'Ƽ' ۿ ϴٴ 򰡹޴´.

ɴٴ 2016 4 ̱MDشϼ 87 Ƿ ۷ι ٱ 1/2ӻ Դ. 2018 9 14ϱ 101 TAK-788 5-180mg پ õ 160mg 1 1ȸ 뷮 Ȯϰ, ڸ ̴. ǥڼ 341 ߴ. 2020 1 ϷѴٴ ȹ̴.

  ֱ ɴ ǥ Ұ TAK-788 ȹ

̱ ǿ(NIH) ϴ ӻƮ ŬƮ̾(Clinical Trials) , ɴٴ TAK-788 2ӻ ȣƮ 7 Ȯϸ鼭 پ ɼ Ÿϰ ִ.

EGFR TKI ų ʾҰ ߽Ű(CNS) ̰ EGFR 20 ȯ CNS ̰ ִ HER2 20 ȯ CNS ̰ ִ EGFR Ǵ HER2 20 ȯ CNS ̰ 鼭 19 Ǵ 21 ġȯ EGFR Ȱ ̸ ȯ CNS ̰ EGFR TKI ־ ̴ ȯ CNS ̰ ׾ ༺ EGFR 20 ȯ Ҽ ȣƮ 6. Ҽ ̿ܿ CNS ̰ EGFR/HER2 ̸ ȯڸ ȣƮ ߴ.

TAK-788 Ҽ ȯ ġε ̴. ɴ 濵 ֱ ۷ݿ TAK-788 , ġ Ҽ ȯ 3ӻ ð ӹߴٰ ǥ ִ.

ߵϰ 2ӻ ܰ...4б 'Ƽ' ȣƮ1 м

ٸ Ƽհ TAK-788 ӻġ ϱ ƴٴ ߷̴. 2ӻ ܰ ߼ӵ ߰м ٴ .

Ʈ ȸ(WCLC 2018) Ƽ 2ӻ ߰м , ְ ORR 55%. Ȯ ORR 43%, Ⱓ(PFS) 5.5 ƴ. ġ TAK-788 ORR Ƽպ , PFS ټ Ϻ ȣƮ Եƴٴ ⿣ ִٴ м̴.

Ʈ ֱ ZENITH20 ۷ι 2ӻ ȣƮ 7 Ȯϸ鼭 Ȱϰ ϰ ִ. 20 Ҽ ܿ 18 ȯڿ 'Ÿ׸(øƼ)' Ҽ ȯڰ ο ȣƮ ߰ƴ. ̹ WCLC 2019 ȸⰣ ߿ ӻ2 ǥϸ鼭 Ȯ뿡 ڽŰ 巯´.

迡 Ʈ 4б ǥ ZENITH20 2ӻ 'ȣƮ1' м . ȣƮ1 ġ ִ EGFR 20 Ҽ ȯڷ, TAK-788 2 ٽȣƮ ߺȴ. ȣƮ1 м , Ƽ ġ ִٴ ̴.
Ȱ (kjan@dailypharm.com) ٸ
  • μ
  • īī
  • ̽
  • Ʈ
  • 0
ñ
/home/dailypharm/issueData2017/
ǰ
0
͸ǰ | Ǹǰ߾ Ģ
ݱ

Ǹ ͸ , Ǹ ̸ ̵ ˴ϴ. ͸ ʸ ϸ, ͸ մϴ.

ڹ(-ڴϾ-ʱ ) ˵ ϸ ȸ Խ ⡯ ĺ Ʈ ׻ ֻܿ ˴ϴ. ο ø Ϲȸ Խ ĺ ڴϾ ȸ ϴܿ ǽð ˴ϴ.

뺸 ϰ ̵ ̿ Ǵ ֽϴ.

  • ۱ǡΰݱ Ÿ Ǹ ħϴ

    α׷ ϰ , ȳϴ Խù

    Ÿ Ǵ 3 ۱ Ÿ Ǹ ħ Խù

  • ٰ 桤 Ѽϴ Խù

    Ư ̿ ο ν 弳

    Ư 븳 ϴ

    Ȯ ȵ ҹ Ű

    弳 , Ӿ

    Ź, ɿ ˵Ǵ ( û )

    Ư ̳ ü ϴ

    Ư ѼϿ ش ûϴ

    Ư (ֹεϹȣ, ȭ, ּ ) Խϴ

    Ÿ ID Ȥ г ϴ

  • Խ Ư ѵǴ

    ʴ

    翡 ߺ

    κ Ͽ ݺ ϴ 쵵

    Խù,

    Ե Խù

    Խù б

  • û ִ

  • Ÿ

    ʿ伺 ̸

    Ÿ ˵Ǵ 縦

    Ÿ  ڰ ʿϴٰ ǴܵǴ

  • Ȯ

    ۱ڷκ , , ϴ

    Ÿ ʻ ħϰų ϴ

    翡 ̿ (Ÿ ID, йȣ )

  • ̻ Ϻ ׿ ̿ 縦 , Ρ ó ֽϴ.

    õ ̴ ҹ Ǵܵǰų ϸ 񽺿 ٶ ʴٰ ǴܵǴ ġ ϰڽϴ.

    رŸ ϸ ڿ ֽʽÿ. ּҴ dailypharm@dailypharm.comԴϴ.

ֽż ݴ
ٺ Ϲݾ ǸŰ (2024 05)
౹ 71
ǰ ְ
ѽŻ÷(10) 3,500 2,300 1,200 3,028
޾(100) 25,000 22,000 3,000 23,304
Ʒγΰ(100) 30,000 27,000 3,000 29,237
īɾ(10g) 8,000 5,500 2,500 6,472
Ľõ򿬰(5g) 5,500 4,000 1,500 5,035
Ź(4) 5,000 3,500 1,500 4,449
ڶ(20) 7,000 5,800 1,200 6,433
(10) 6,000 4,000 2,000 4,914
Ժ(10) 4,000 3,000 1,000 3,543
ڱ׸(20) 5,000 3,800 1,200 4,622
ť(10) 3,500 2,300 1,200 2,828
Ȱť(1) 1,200 1,000 200 1,140
Ǯɾ(3.3ml) 25,000 22,000 3,000 24,214
޵𿬰(10g) 7,000 5,000 2,000 6,162
öŸ(34) 13,000 10,000 3,000 12,089
뽺ī(20g) 22,000 18,000 4,000 20,358
ġ(1) 1,100 1,000 100 1,000
ӽ÷(21) 10,000 7,500 2,500 8,998
ͺ(10) 3,500 2,300 1,200 3,138
ݿ(1ڽ) 3,000 2,500 500 2,947
׶÷糪ƮŸ(6) 8,000 7,000 1,000 7,973
߽Ÿ(120) 70,000 40,000 30,000 54,203
Źĸ(10ĸ) 3,000 2,000 1,000 2,941
Ÿ̾(120) 60,000 40,000 20,000 49,168
տ(60ĸ) 30,000 24,000 6,000 27,235
Ÿ̷ER(6) 2,500 2,500 0 2,500
ٿ(30g) 12,000 9,000 3,000 11,221
(120) 25,000 18,000 7,000 21,716
Ʒ(6) 4,000 3,000 1,000 3,509
ǽõĸ(270ĸ) 120,000 85,000 35,000 106,875
B(120) 70,000 60,000 10,000 62,308
׳(10) 3,000 2,000 1,000 2,684
6̺(10) 3,500 2,000 1,500 2,965
(60) 250,000 200,000 50,000 224,000
Ⱦ 12,000 9,000 3,000 10,494
̰źĸ(60ĸ) 25,500 22,000 3,500 23,942
Ųť(20) 5,500 4,500 1,000 4,823
λ絹÷(100) 37,000 29,000 8,000 31,878
ü



ͳݽŹϹȣ: 00048 | 2005.09.09 | 2005.09.09 | : | : ȣ
ּ: ı 128 SK V1 GL ƮνƼ A 401ȣ
ȭ : 02-3473-0833 |ѽ : 02-3474-0169 | ûҳ⺸ȣå(å ű)
Contact dailypharm@dailypharm.com for more information
ϸ () ϴ ۱ǹ ˵Ǹ, 縦 ֽϴ.