24.03.29 () 22:48

Dailypharm

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鿪׾ ɵ𺸡ŰƮ١ӻ ''
Ȱ 2016-10-11 12:15:00
鿪׾ ɵ𺸡ŰƮ١ӻ ''
Ȱ 2016-10-11 12:15:00
[DP] ȸ 1ġ ...?



ɵ(Ϻ縿) ŰƮ(Ѹָ).

о߿ ϴٴ ̵ 鿪׾ ޿ ̷ ׳ Ű ϴ. ȸ(ESMO 2016) ִ ũ ϰ ࿡ ̾. ۷ι ڷḦ Ϻθ ӻ󿬱 ƴ.

ϴ μ ŰƮٰ 켼غδ. 9 ǥ 'KEYNOTE-024' 3 ӻ󿬱 ġμ ÷ƼѰ ׾ ü ɼ . ݸ 8 BMS ְ ֹ̾ 'Checkmate-026' ̷ ƽ .

׷ δ 'PD-L1'̶ Ŀ ־.

ŰƮ 1 ܵ, 50% = MSD ŰƮٴ 1ġ ̴.

NEJM 10 9 ¶ǿ Ǹ 'KEYNOTE-024' . ÷ƼѰ ׾() ŰƮٱ Ⱓ(PFS) 10.3, 6.7 Ǵ 50% ƴ(HR 0.50; 95% CI, 0.37-0.68). 6° ü (OS) ŰƮٱ 80.2%, 72.4%(HR 0.60; 95% CI, 0.41-0.89).

(ORR) ŰƮٱ 44.8% (27.8%) , ӱⰣ ߾Ӱ ʾ (6.3) ̸ Ÿ´.

ġ ̻ ŰƮٱ 73.4%, 90.0% Ÿ, 3~5 ̻ Ÿ ȯڵ 26.6% 53.3% .

ָؾ (305) ġ Ҽ(NSCLC) PD-L1 50% ̻ ȯڵ ߴٴ ̴. ǥ׾ ߵ ִ EFGR̳ ALK ȯڵ ܽ״.

ָϴ Ʈ ٷ . 鿪׾ ȯڱ ߱⿡ ǥؿ Ǵ ÷ƼѰ ׾ ص پ ȿ ־ٴ .

Ǵ ̴ȣ (ƻ꺴 系) "KEYNOTE-024 ŰƮ 1ġ ɼ ϴ ͷ Ȱ "̶鼭 "鿪׾ ׾ ̱ ݵ ̿Ŀ ʿϴ. PD-L1 ҿ Ŀ ϴ μ ּ"̶ ߴ.

ŰƮٴ ׾ 'KEYNOTE-021' 2ӻ󿡼 س´(Lancet Oncology 10 9). ׾ ŰƮٸ ߰ Ⱓ 13 þٴ (13 vs. 8.9).

ֿ Ӹ(Stefan Zimmermann) ( ܴк) " ȯڿ ο ȴ. ó Ҽ ȯ ġμ 鿪׾ ɼ Ȯϰ ƴ" е .

߿ɵ, PD-L1 5% ? ܵ = ٽ 'Checkmate-026' ƿͺ.

8 Checkmate-026 ž ߴ BMS ESMO ȸ ߴ. ش PD-L1 5% ̻ Ҽ ȯڰ ̾ٴ ŰƮ ȭ ȴ. ӻ 'ڸߴ' Ŵ .

м ɵ ġᱺ Ⱓ(PFS) 4.2, ÷ƼѰ ׾ 5.9 Ҵ. ü Ⱓ(OS) ɵ𺸱 14.4 (13.2) ǹִ ġ ƴϾ.

ġ ̻ ߻ ɵ𺸱 71%, 92% . ׳ ེ Ҽ ȯڿ ȿ ô CheckMate-017 CheckMate-057 Ⱓ(durable response) 2谡 þ ߴٴ κ̴.

̴ȣ "ϴ ȯڿ Ⱓ ȿ ӵȴٴ , ǥ׾ ׾ 񱳵 鿪׾ Ư"̶鼭 "ɵ PD-L1 ׾ ̱ ̴. PD-L1 ̴, ٸ 鿪׾ ϴ ٸ ãƾ Ѵ" ߴ.

縯Ǵ (Z𺴿 系) "ɵ ϳ ׾ ʳ ȴ", " ٸ 鿪׾ ϰų ׾ ɵ𺸸 ߰ϴ (sequential) ϴ , PD-L1 ̴ ϴ" ǰ ´.

̿ ɵ𺸴 1ġμ ɵ𺸿 ɵ𺸿 ׾ ϴ CheckMate-227 ̴. ȯڵ鵵 ϴ 1000 Ѵ Ը 2018 ǥ ޷ ִ. ̱ӻȸ(ASCO 2016) ̸ 븦 Ȳ.

̴ȣ " CheckMate-227 1 鿪׾ ع õ "̶鼭 "̹ ȯڵ ư, ̸ (preliminary data) ִ" ٺô.
Ȱ (kjan@dailypharm.com) ٸ
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ֽż ݴ
౹ Ϲݾ Top 100(03)
ǰ Ƚ Ǹűݾ
1 Ÿ̷500mg(10) 23638 33104 101,505,000
2 Ȱť 13391 83427 97,389,700
3 Ǹť 10902 91595 73,069,159
4 ݿ 11997 88325 71,846,700
5 ũũ 4431 4720 52,151,000
6 뽺ī 20g 2332 2418 49,544,700
7 319 12291 44,946,300
8 Ź ĸ(10ĸ) 10732 15961 42,562,800
9 S 676 1227 42,429,350
10 ݴ ť÷ 8546 11210 42,423,060
11 ̰źĸ(60ĸ) 1292 2602 37,202,100
12 ġ 8140 41776 36,792,300
13 öŸ(34) 2501 3833 35,705,600
14 ׶÷ ƮŸ 3353 4312 35,035,660
15 Ʒγΰ̾(120) 657 810 34,246,900
16 ġ̽Ʈġ120g 2388 3282 34,107,490
17 öŸ(40) 2100 2586 34,093,300
18 ٿ 30g 2899 5594 33,943,700
19 (120) 1218 2384 32,914,000
20 ڶ-(40) 1737 3804 28,306,900
21 Ժ 5110 8423 27,914,600
22 Ź 3783 5019 27,081,000
23 ƽŸ 434 825 26,872,500
24 ׶÷ ݵ& Ʈ 1824 2172 25,848,300
25 (10) 8429 12233 25,619,101
26 ȲûɿŹ50ml(õ) 1192 2335 25,361,000
27 ݴ ݵť÷ 5324 6920 25,224,900
28 Ÿ̷500mg(30) 2468 3258 24,699,390
29 Ľõ򿬰10׶ 3091 3369 24,306,500
30 6089 25744 24,196,461
31 Ʒ 3226 7806 24,186,252
32 6̺(30ĸ) 2737 3245 23,701,750
33 ġ̽Ʈġ150g 1401 1754 23,469,900
34 ũ 1907 1963 23,302,401
35 λ絹÷(100) 671 1981 22,752,400
36 ݿ 5552 7933 22,665,600
37 ťýȾ0.5ml*60 1158 1319 22,004,000
38 D-׳ 2074 2207 21,799,902
39 Ľõ򿬰5g 3700 3954 20,580,200
40 뽺ī 10g 1603 1663 20,406,600
41 ӽ÷ 1879 2250 20,176,000
42 öŸ 3232 7567 19,371,321
43 ȲûɿŹ50ml() 1585 3803 19,128,000
44 Ȳûɿȯ() 255 1579 19,058,500
45 ƽƮ(150) 195 351 18,535,100
46 Ÿ̷8ð̾˼ 4493 6574 18,407,000
47 ʽ÷÷ 2748 3217 18,376,001
48 īɾ10g 2552 2817 18,221,600
49 Ʒγΰ(100) 525 1187 18,136,800
50 (10) 2814 3718 18,035,700
51 6̺꿬ĸ(10ĸ) 4711 6546 17,234,600
52 ھ ߽20ml 1500 1754 17,208,900
53 ƽŸ 313 594 16,459,972
54 ݴŰ÷ 3393 4385 15,960,800
55 ̵Ⱦ 14ml 2463 2769 15,949,650
56 ǥȲûɿ 50ml 1061 3758 15,544,646
57 ڷƮ 2mg (Ʈ) 693 1630 15,516,200
58 Ź 2643 3839 15,388,600
59 ѺŸC1000mg 814 2828 15,249,703
60 λ絹÷(270) 194 737 15,225,500
61 밢()(18) 1795 2220 15,094,100
62 ̵Ⱦ 14ml 2416 2576 14,910,600
63 λ絹(100) 491 907 14,826,800
64 ׺ƽĸ 294 546 14,789,500
65 翬ĸ(120ĸ) 372 387 14,722,300
66 Ź̵ 3100 3837 14,720,200
67 Ʈ0.1%й 1182 1495 14,673,700
68 ȭ 4074 18105 14,639,465
69 Ʒ 2856 4634 14,629,300
70 ѽŻ÷(10) 3458 5196 14,582,200
71 ׺ǵ 1246 7135 14,399,712
72 ݴŰ÷ 3107 3696 14,384,750
73 ÷ 3969 4682 14,254,868
74 ƼǪīŸö󽺸 2531 4745 13,924,700
75 ̵Ⱦ׼ 14ml 2151 2411 13,871,800
76 īٿĸ(60ĸ) 299 427 13,498,500
77 ΰ 155 206 13,325,000
78 2480 9352 13,106,010
79 ξ 487 5011 13,096,210
80 ƼǪ Ŀ 1714 3762 13,033,911
81 īɾ 6g 2647 2864 12,758,350
82 10 1610 2720 12,753,338
83 ƽúŰ÷(10) 2340 2566 12,706,610
84 ġĸ(60ĸ) 452 984 12,697,600
85 տ翬ĸ(80ĸ) 349 449 12,559,600
86 Ǫ÷ 3092 4079 12,536,300
87 īڿ;(300) 425 459 12,408,600
88 Ÿ̷ݵ忡 2519 3686 12,349,800
89 2% 120ml 683 707 12,166,600
90 ġĸ(120ĸ) 241 251 12,094,000
91 ȯ 1945 2815 12,000,300
92 Ŭƾ 972 1013 11,992,500
93 ƼǪ Ŀ 1949 4686 11,989,100
94 ݴ ť÷ 2523 3104 11,948,900
95 ǥȲûɿ50ml(õ⺯) 584 1190 11,875,100
96 1100 1463 11,805,800
97 ؽ 1141 1198 11,802,000
98 ڸŰĸ 2134 2516 11,677,500
99 Ⱦ0.5ml 573 659 11,636,000
100 ƮƮŰ& 1615 2330 11,516,140
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