[2] 츮 ް
η, ڻڵ ΰ 1⵿ ް6 ް3 1:1 Ĵ ü ȭ Դٰ Ѵ. ڿ Ĺ (Ǯ) ü ȭ ſ ް6 ް3 1:1̸ ̷ ڿ Ǯ Ӱ Ե 100% ް6 ް3 1:1̴.
ΰ ֿ ȭ Ұ, Ĺ, ް, ߰, Ա ̷ ް ϸ ڿ ü ް6 ް3 1:1 Ǵ ̴.
⼭ 츰 ΰ ް3 ް6 ȣ ȯų ִ omega-3 desaturase ȿҸ ʱ ȣȯ Ұϴٴ ̹ ˰ ִ. ռ 翬 ص ̴. ֱ 150Ⱓ, ȭ , ٸ Ǵ Ȯ Դ ĻȰ ۽ ȭ ݱ 1Ⱓ ϰ Դ ް ū Ű ƴ.
Ư Ĵܿ ް6 ް3 15:1 16.7:1 мǰ ִ. , ȭ ᰡ ٴ ̴. Ⱓ ȯ, , ٰ, ڰ鿪 ȯ ġ ʾҴ ȯ ߴ.
츮 ̹ ް6 LA(linoleic acid) 밡 LDLݷ ȭ, , ް3 EFA ϴ ˰ ƴ. ٸ ̷ ȯ ũ ȯ ް6 ް3 ʷ ִ.
ǰ ε ̽ ü ް6/ް3 (AA/EPA , ް6/ް3) (A), ù° 28ϰ ⸧(ް6) 160g ް ϰ (B), 4ְ þƿⰣ ģ ٽ ι° ̽ ް (C), ι° 28ϰ ä Ƹ(ް3) 160g ް (D) ִ.
ʹ ⸧ (A)(9.25, 4.23) (B)(13.84,4.73), ä Ƹ (C)(9.73, 4.62) (D)(8.72, 4.43)̾. ⸧ AA ް6 ߰, ä Ƹ ߴ. ܱⰣ 赥 ް6 ް3 ̻ 1:1 밡 ü ް ϰ Ű ̴.
Michael A. Schimidt 'SMART FATS' (ʼ) ұ(ް6 ) ʷϴ (Signs of Fatty Acid Imbalance) . Ǻ, , , (ȭ ), Ƿ , (soft nail), Ǿ ģ Ǻ(alligator skin), ˷ , Ҿ 鿪 ý, Ǵ Ƿ, ϰ ʹ ٷⰡ ( ð ), ص , μ , ൿ(hyperactivity), ȱ, Ǻ(Ư , chicken skin), н Ǵ , , â Ǻ, ճ ߵڲġ ̴.̷ ̸ ϴ ü ް6 ް3 ұ¸ ǽ ʿ䰡 ִٰ Ѵ.
غ 1̶ ð ް6 ް3 1:1 ߾ ȭ Դµ ִ ȯ ް6 ް3 1:1 ƴ ġ Ȳ ִ. ٽ ϸ ް6 vs ް3 1:1 ǰϰ Ȱ ϵ α Դٴ ̴. 1:1 ũ ȯ ȥ ٿ ۿ .
ũ ȭ ĻȰ Ư¡ ʼ ¿ ȭ ̴. 鼭 ڵ ڰ , , 輳, ̰ ġ° Ұ ġ ִ.
ưȭ(Artherosclerosis) (endothelium) ݷ ħϸ鼭 ǰ, Ǽ Ͼ (artheroma) Ǵ ȯ̴. 츮 ̹ 5-LO(lipoxygenase) AA (arachidonic acid)κ Ǵ leukotriene ۿ ˰ ִ. 5-LO (gene promoter) Ư (polymorphism) ưȭ , 5-LO (substrate) 뵵 ȣ ۿ Ѵٴ .
ڵ Los Angeles Arherosclerosis study ߳ 470 5-LO (genotype), 浿 ߸ β(carotid intima-media thickness), Ŀ(markers of inflammation), CRP, IL-6, ̼ AA, DHA, EPA, LA, ALA ߴ. 5-LO ̼ (varient genotypes)6.0%, , , Ű, , mean intima-media thickness( ߸ β) Ϲ(wild-type) 븳(common allele) 麸 2 ̼ 븳(varient allele) 80+19m ־. ٺм(multivariate analysis) 2 varient allele ߸ β 62m Ͽ, ȯ ϳ 索 쿡 β 64m ϰ ǥƴ.
AA̴ Ư (genotype) Ų ݸ, EPA, DHA ް3 ̼ ̷ ȿ ȭ״. Դٰ 2 ̼ 븳(varient allele) CRP Ϲ 븳(common allele) 2 Ÿ. 5-LO ̼(genetic variation) ưȭ ڸ ư ̿ ڰ ȣۿ ̷ ڸ ܿ ް6 lekotriene Ű ϴ ݸ, ް3 ϴ ƴ.
̷ ̼ (varient genotypes) ٸ Ư ƽþư Ǵ α 19.4%, 24%, 18.2% да3.6%, д 3.1% Ÿ. ̵ AA LA밡 ƺ ߸ β(intima-media thickness) Ϲ 븳 麸 ξ ־. ݴ ް3 ȿ Ϲ 븳 麸 ̼ 븳 ξ ũ Ÿ. ᱹ ̴̾߱.
̷ ͵ ̿ ȯ ġῡ ־ ο ǥ ʿ ϰ ִ. ѱε ̷ ̼ ƽþư̹Ƿ ް6 ް3 ʿ䰡 ִ. ѱ ڱ ĻȰ ϸ鼭 1Ⱓ ̻ ް6 ް3 1:1 ı ۵ư ̷ ټ ް ұ ϱ ̴.
ȸ ܱⰣ ϸ鼭 ؿ Ĺȭ ѱ ü ū δ ٰ ̰ ᱹ ı ȯ, 鿪ȯ ͰǴ ۱ Ȳ ǰ ִٴ ߷ ִ.
ް6 ް3 10~17:1 ̻ 1:1 ߱ ؼ ް3 밡 ̴.